Restless legs syndrome in patients with amyotrophic lateral sclerosis
Identifieur interne : 000557 ( Main/Exploration ); précédent : 000556; suivant : 000558Restless legs syndrome in patients with amyotrophic lateral sclerosis
Auteurs : Daniele Lo Coco [Italie] ; Federico Piccoli [Italie] ; Vincenzo La Bella [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-11-15.
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Abstract
We aimed to evaluate the frequency and determinants of restless legs syndrome (RLS) in a group of 76 patients with amyotrophic lateral sclerosis (ALS) and 100 control subjects. A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the RLS severity scale. RLS was significantly more frequent in patients with ALS (ALS/RLS+) than in control subjects (25% vs. 8%; P = 0.002). Compared with control subjects, patients with ALS/RLS+ showed shorter history of RLS complaints and higher frequency of symptoms occurrence. Moreover, compared with those without RLS, patients with ALS/RLS+ showed increased functional impairment and more often reported sleep complaints. Multivariate logistic regression confirmed the association between RLS and functional impairment. Our findings suggest that RLS should be considered as a possible cause of disrupted sleep in patients with ALS and should be specifically investigated in these patients. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23261
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-11-15">2010-11-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2658">2658</biblScope><biblScope unit="page" to="2661">2661</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">209CAB0101943926BE05D231C3F761EBC298CA21</idno><idno type="DOI">10.1002/mds.23261</idno><idno type="ArticleID">MDS23261</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>amyotrophic lateral sclerosis</term><term>insomnia</term><term>neurodegenerative disease</term><term>restless legs syndrome</term><term>sleep</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to evaluate the frequency and determinants of restless legs syndrome (RLS) in a group of 76 patients with amyotrophic lateral sclerosis (ALS) and 100 control subjects. A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the RLS severity scale. RLS was significantly more frequent in patients with ALS (ALS/RLS+) than in control subjects (25% vs. 8%; P = 0.002). Compared with control subjects, patients with ALS/RLS+ showed shorter history of RLS complaints and higher frequency of symptoms occurrence. Moreover, compared with those without RLS, patients with ALS/RLS+ showed increased functional impairment and more often reported sleep complaints. Multivariate logistic regression confirmed the association between RLS and functional impairment. Our findings suggest that RLS should be considered as a possible cause of disrupted sleep in patients with ALS and should be specifically investigated in these patients. © 2010 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Sicile</li></region><settlement><li>Palerme</li></settlement><orgName><li>Université de Palerme</li></orgName></list><tree><country name="Italie"><region name="Sicile"><name sortKey="Lo Coco, Daniele" sort="Lo Coco, Daniele" uniqKey="Lo Coco D" first="Daniele" last="Lo Coco">Daniele Lo Coco</name></region><name sortKey="La Bella, Vincenzo" sort="La Bella, Vincenzo" uniqKey="La Bella V" first="Vincenzo" last="La Bella">Vincenzo La Bella</name><name sortKey="Lo Coco, Daniele" sort="Lo Coco, Daniele" uniqKey="Lo Coco D" first="Daniele" last="Lo Coco">Daniele Lo Coco</name><name sortKey="Piccoli, Federico" sort="Piccoli, Federico" uniqKey="Piccoli F" first="Federico" last="Piccoli">Federico Piccoli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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